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62 and McNeil et al
Notably, while smoking-associated alterations in innate immune responses largely resolved after cessation, adaptive immune changes persisted long after individuals quit smoking, consistent with epigenetic reprogramming of immune cells (66)
Alternative products such as e-cigarettes and heated tobacco products have gained increasing market share in recent years 44,45 complicating any estimates of smoking-related burden, as their long-term health risks for exclusive and dual users are still unclear
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